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What are doxazosin tablets?

DOXAZOSIN (Cardura reg;) is an antihypertensive. Doxazosin lowers, but does not cure, high blood pressure. It works by relaxing your blood vessels. It also can be used to treat enlargement of the prostate gland in men.

What should I tell my health care provider before I take this medicine?

They need to know if you have any of the following conditions:

kidney disease
liver disease
low blood pressure
an unusual or allergic reaction to doxazosin, other medicines, foods, dyes, or preservatives
pregnant or trying to get pregnant
breast-feeding

How should I take this medicine?

Take doxazosin tablets by mouth. Follow the directions on the prescription label. Swallow the tablets with a drink of water. Take your doses at regular intervals even if you feel better. Do not take your medicine more often than directed. Do not stop taking except on your prescriber's advice.

Contact your pediatrician or health care professional regarding the use of this medicine in children. Special care may be needed.

What if I miss a dose?

If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.

What drug(s) may interact with doxazosin?

Do not take doxazosin if you are taking the following medications:

other alpha-blockers such as alfuzosin, phentolamine, phenoxybenzamine, prazosin, tamsulosin, terazosin
tadalafil
vardenafil

Doxazosin may also interact with the following medications:

antiinflammatory drugs (NSAIDs, such as ibuprofen)
dopamine
female hormones, including contraceptive or birth control pills
medicines for colds and breathing difficulties
medicines for high blood pressure
metaraminol
methoxamine
monoamine oxidase inhibitors (Azilect reg;, Eldepryl reg;, Emsam reg;, Marplan reg;, Nardil reg;, Parnate reg;, Zelapar trade;)
sildenafil (doses of sildenafil higher than 25 mg should be taken at least 4 hours apart from taking doxazosin)
water pills

Tell your prescriber or health care professional about all other medicines you are taking, including nonprescription medicines, nutritional supplements, or herbal products. Also tell your prescriber or health care professional if you are a frequent user of drinks with caffeine or alcohol, if you smoke, or if you use illegal drugs. These may affect the way your medicine works. Check with your prescriber or health care professional before stopping or starting any of your medicines.

What side effects may I notice from taking doxazosin?

Side effects that you should report to your prescriber or health care professional as soon as possible:

Rare or uncommon:

difficulty breathing, shortness of breath
prolonged painful erection of the penis (priapism)

More common:

dizziness or drowsiness
fainting spells
numbness in hands or feet
palpitations or pounding heart, irregular heartbeat
swelling of the legs or ankles

Side effects that usually do not require medical attention (report to your prescriber or health care professional if they continue or are bothersome):

headache
nausea
unusual tiredness

What should I watch for while taking doxazosin?

Check your blood pressure regularly. Ask your prescriber or health care professional what your blood pressure should be and when you should contact him or her.

You may feel drowsy or dizzy. Do not drive, use machinery, or do anything that requires mental alertness until you know how doxazosin affects you. To reduce the risk of dizzy or fainting spells, do not sit or stand up quickly. Avoid alcoholic drinks; they can make you more drowsy, and increase flushing and rapid heartbeats. Take doxazosin at bedtime to lessen the effects of drowsiness and dizziness, but be careful if you have to get up during the night. Drowsiness and dizziness are more likely to occur after the first dose, after an increase in dose, or during hot weather or exercise. Dizziness can decrease once your body adjusts to this medicine.

Although extremely rare in men taking doxazosin, contact you health care provider immediately if you experience prolonged and painful erection of the penis which is unrelated to sexual activity (priapism). If not brought to immediate medical attention, priapism can lead to permanent erectile dysfunction (impotence).

Do not take nonprescription medicine for weight-loss without asking your prescriber or health care professional. Also, do not take cough and cold, hay fever or sinus medications without asking your prescriber or health care professional.

If you are going to have surgery, tell your prescriber or health care professional that you are taking doxazosin.